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4359 matches
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organism
protein
1)
Homo sapiens
RAB11B - Ras-related protein Rab-11B; The small GTPases Rab are key
regulators
of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling,
regulating
apical recycling of several
transmembrane
proteins including cystic fibrosis
transmembrane
conductance
regul
[...]
[a.k.a. Ras-related protein Rab-11B, 9230, AAI10082.1]
2)
Homo sapiens
TM4SF20 -
Transmembrane
4 L6 family member 20; Polytopic
transmembrane
protein that inhibits
regulated
intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which
transmembrane
helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called '
regulated
alternative translocation' (RAT) and
regulates
the function of the
transmembrane
protein. Bel [...]
[a.k.a. BC035754, NM_024795.4, AY358671]
3)
Homo sapiens
TSPAN33 - Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity).
Regulates
maturation and trafficking of the
transmembrane
metalloprotease ADAM10. Negatively
regulates
ligand-induced Notch activity probably by
regulating
ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7.
[a.k.a. PEN., CCDS5810.1, XP_006716023.1]
4)
Homo sapiens
SIT1 - Signaling threshold-
regulating
transmembrane
adapter 1; Negatively
regulates
TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.
[a.k.a. SIT1_HUMAN, CAC81313.1, uc003zxe.3]
5)
Homo sapiens
STOM - Erythrocyte band 7 integral membrane protein;
Regulates
ion channel activity and
transmembrane
ion transport.
Regulates
ASIC2 and ASIC3 channel activity; Belongs to the band 7/mec-2 family.
[a.k.a. 2040, NM_004099, NP_001257455.1]
6)
Homo sapiens
TSPAN14 - Tetraspanin-14;
Regulates
maturation and trafficking of the
transmembrane
metalloprotease ADAM10. Negatively
regulates
ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity).
[a.k.a. NP_001338196.1, TM4SF14, NP_001338200.1]
7)
Homo sapiens
CFTR - Cystic fibrosis
transmembrane
conductance
regulator
; Epithelial ion channel that plays an important role in the
regulation
of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the
regulation
of the pH [...]
[a.k.a. ABC87057.1, 2BBO, A0A3B3ITE0]
8)
Homo sapiens
TMEM64 -
Transmembrane
protein 64; Positively
regulates
TNFSF11-induced osteoclast differentiation. Acts as a
regulator
of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively
regulates
[...]
[a.k.a. ENST00000523902, AB015752, NP_001008495.2]
9)
Homo sapiens
TSPAN15 - Tetraspanin-15;
Regulates
maturation and trafficking of the
transmembrane
metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2 (By similarity). Negatively
regulates
ligand-induced Notch activity probably by
regulating
ADAM10 activity ; Belongs to the tetraspanin (TM4SF) family.
[a.k.a. Transmembrane 4 superfamily member 15, hsa:23555, TSPAN15-203]
10)
Homo sapiens
PLA2G6 - 85/88 kDa calcium-independent phospholipase A2; Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide- induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in
regulating
transmembrane
ion flux in glucose- stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2- induced chemotaxis through
regulation
of F-actin polymerization at the pseudopods.
[a.k.a. ENSP00000412629, PLA2G6-225, ENST00000335538]
11)
Homo sapiens
GNAQ - Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various
transmembrane
signaling systems.
Regulates
B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity.
Regulates
chemotaxis of BM- derived neutrophils and dendritic cells (in vitro) (By similarity). Belongs to the G-alpha family. G(q) subfamily.
[a.k.a. R-HSA-388396, GAQ, R-HSA-162582]
12)
Homo sapiens
TMEM47 -
Transmembrane
protein 47;
Regulates
cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May
regulate
F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively
regulate
activity of FYN and subsequently the abundance of nephrin (By similarity); Belongs to the TMEM47 family.
[a.k.a. HGNC:18515, BCMP1, transmembrane 4 superfamily member 10]
13)
Homo sapiens
TMEM150A -
Transmembrane
protein 150A;
Regulates
localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. Acts as a
regulator
of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. May also play a role in fasting-induced catabolism (By similarity).
[a.k.a. ENSP00000389177, ENST00000463363, TMEM150A-207]
14)
Homo sapiens
SHISA7 - Protein shisa-7;
Transmembrane
protein that
regulates
gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May
regulate
the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 [...]
[a.k.a. SHISA7-201, ENST00000376325, NP_001138648.1]
15)
Homo sapiens
TMEM170B -
Transmembrane
protein 170B; Negatively
regulates
the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family.
[a.k.a. 100113407, uc010jpa.5, NM_001100829.2]
16)
Homo sapiens
LAX1 - Lymphocyte
transmembrane
adapter 1; Negatively
regulates
TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
[a.k.a. ENSP00000406970, UPI00002056AF, NM_017773.3]
17)
Homo sapiens
TSPAN10 - Tetraspanin-10;
Regulates
maturation of the
transmembrane
metalloprotease ADAM10; Belongs to the tetraspanin (TM4SF) family.
[a.k.a. OCSP, NM_031945.4, Q8N548]
18)
Homo sapiens
TM6SF2 -
Transmembrane
6 superfamily member 2;
Regulator
of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase. Belongs to the TM6SF family.
[a.k.a. ENST00000586107, ENSP00000374014, Transmembrane 6 superfamily member 2]
19)
Homo sapiens
VPS13C - Vacuolar protein sorting-associated protein 13C; Necessary for proper mitochondrial function and maintenance of mitochondrial
transmembrane
potential. Involved in the
regulation
of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization.
[a.k.a. ENST00000395896, ENST00000560637, ENSP00000323673]
20)
Homo sapiens
TMEM33 -
Transmembrane
protein 33; Acts as a
regulator
of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules. Positively
regulates
PERK-mediated and IRE1-mediated unfolded protein response signaling. Belongs to the PER33/POM33 family.
[a.k.a. ENST00000513702, TMEM33-202, NX_P57088]
4359 matches
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